Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

Dehydro-ryanodine (60 mg., 0.125 mmol), N-(p-n-butoxybenzoyl)-β-alanine (40 mg. 0.15 mmol) and DMAP (2 mg., 0.02 mmol), dried over P2O5, were dissolved in a solvent mixture of CH2Cl2 (10 ml.) and tetrahydrofuran (0.1 ml) dried over Molecular Sieve. To the stirred solution dicyclohexylcarbodiimide (35 mg., 0.15 mmol) was added at once and the reaction mixture maintained at room temperature for 6 hours. Water (0.1 ml) was added and stirring continued for 30 minutes. The solids formed (dicyclohexylurea) were filtered and washed twice with CH2Cl2.

1. customdried over Molecular Sieve

ORDレコード

ord-2a85d5dff5264231b1aaec2ff0873d86

出典データセット

uspto-grants-1997_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05679701