Ethylmorpholine → HCID 15295998、化合物
反応式
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH:12][CH2:13][C:14]([OH:16])=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N1CCOCC1)C.[N:25]([CH:28]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:29]([O:31][CH3:32])=[O:30])=[C:26]=[O:27]>CN(C)C=O>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:13][C:14]([OH:16])=[O:15])[C:26]([NH:25][CH:28]([C:29]([O:31][CH3:32])=[O:30])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:27])=[O:7])([CH3:4])([CH3:2])[CH3:3]参加物
5
反応条件
- 温度
- 100 °C
実験手順
2.8 g (12 mmol) of (3-tert-butoxycarbonylaminopropyl)glycine and 1.4 g (12 mmol) of N-ethylmorpholine are dissolved in 300 ml of dimethylformamide. 2.3 g (12 mmol) of methyl α-isocyanatophenylacetate are added dropwise at 100° C. The mixture is stirred at 100° C. for 1 h, allowed to cool down to room temperature, concentrated and chromatographed on silica gel using ethyl acetate/methanol 8:2.