1,2-Dichloroethane → 4-chloro-N-phenethylbenzenesulfonamide

HRID 1490364ノート

反応式

HRID 1490364 の反応式
C(Cl)CCl.[C:5]1([CH2:11][CH2:12][NH2:13])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[OH-].[Na+].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.O>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:13][CH2:12][CH2:11][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)(=[O:25])=[O:24])=[CH:19][CH:18]=1

参加物

7

反応物 4

HCID 111,2-DichloroethaneHCID 1001PhenethylamineHCID 73984-Chlorobenzenesulfonyl chlorideHCID 14798Sodium Hydroxide

生成物 1

HCID 7228614-chloro-N-phenethylbenzenesulfonamide

試薬・触媒・溶媒 2

HCID 74236Tetrabutylammonium Bromide触媒HCID 962Water溶媒

実験手順

To a mixture of 150 ml of ethylene chloride and 150 ml of water are added 30.3 g of 2-phenylethylamine, 12 g of sodium hydroxide and 0.5 g of tetrabutylammonium bromide. 65.5 g of 4-chlorobenzenesulphonic acid chloride are added to the mixture in batches with stirring. After 30 minutes the organic phase is separated off, evaporated down and the residue is recrystallised from toluene.

後処理

  1. customAfter 30 minutes the organic phase is separated off
  2. customevaporated down
  3. customthe residue is recrystallised from toluene

出典と根拠

ORDレコード
ord-67782c2be1ce455088bebafa349fdd7c
出典データセット
uspto-grants-1997_10
特許番号
US05681961

反応ノート

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