1,2-Dibromobenzene → 2-(3,4-Dibromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

HRID 1490554ノート

反応式

HRID 1490554 の反応式
Brc1ccccc1Br>C1=CCCC=CCC1.C1=CCCC=CCC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC1CCCC1.C[OH2+].C[OH2+].[Ir].[Ir].c1ccc(N2B(B3Nc4ccccc4N3c3ccccn3)Nc3ccccc32)nc1>CC1(C)OB(c2ccc(Br)c(Br)c2)OC1(C)C

参加物

6

反応物 1

HCID 114141,2-Dibromobenzene

生成物 1

HCID 467394342-(3,4-Dibromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane収率 98%

試薬・触媒・溶媒 4

HCID 2733548Bis(pinacolato)diborane試薬HCID 1223807993-pyridin-2-yl-2-(3-pyridin-2-yl-1H-1,3,2-benzodiazaborol-2-yl)-1H-1,3,2-benzodiazaborole試薬HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium触媒HCID 138539Cyclopentyl methyl ether溶媒

反応条件

温度
80 °C

実験手順

The general procedure A was followed using 1,2-dibromobenzene (58.6 uL, 0.5 mmol) and B2pin2 (126.9 mg, 0.5 mmol, 1.0 eq.) as starting material. The resulting mixture was allowed to stir 16 hours at 80 oC. 5j was obtained as colorless oil (178.2 mg, 98%) after purification by silica gel flash chromatography (EtOAc/PE=1:50 v/v).

出典と根拠

ORDレコード
ord-baadeffb87484aadb662317cb7d23eb1
出典データセット
Borylation dataset from Roche

反応ノート

読み込み中…