Dimethyl isophthalate → Dimethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isophthalate
反応式
COC(=O)c1cccc(C(=O)OC)c1>C1=CCCC=CCC1.C1=CCCC=CCC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC1CCCC1.C[OH2+].C[OH2+].[Ir].[Ir].c1ccc(N2B(B3Nc4ccccc4N3c3ccccn3)Nc3ccccc32)nc1>COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)cc(C(=O)OC)c1参加物
6
反応物 1
生成物 1
試薬・触媒・溶媒 4
反応条件
- 温度
- 100 °C
実験手順
The general procedure A was followed using dimethyl isophthalate (97.1 mg, 0.5 mmol) and B2pin2 (126.9 mg, 0.5 mmol, 1.0 eq.) as starting material. The resulting mixture was allowed to stir 16 hours at 100 oC. 5k was obtained as white solid (151.1 mg, 95%) after purification by silica gel flash chromatography (EtOAc/PE=1:15 v/v). m.p.: 126-127 oC.
出典と根拠
- ORDレコード
- ord-5dc4a3574eaf41f4b2775be895690305
- 出典データセット
- Borylation dataset from Roche
反応ノート
読み込み中…
