2-Bromothiophene → 2-(5-Bromothiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

HRID 1490563ノート

反応式

HRID 1490563 の反応式
Brc1cccs1>C1=CCCC=CCC1.C1=CCCC=CCC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC1CCCC1.C[OH2+].C[OH2+].[Ir].[Ir].c1ccc(N2B(B3Nc4ccccc4N3c3ccccn3)Nc3ccccc32)nc1>CC1(C)OB(c2ccc(Br)s2)OC1(C)C

参加物

6

反応物 1

HCID 138512-Bromothiophene

生成物 1

HCID 117377972-(5-Bromothiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane収率 96%

試薬・触媒・溶媒 4

HCID 2733548Bis(pinacolato)diborane試薬HCID 1223807993-pyridin-2-yl-2-(3-pyridin-2-yl-1H-1,3,2-benzodiazaborol-2-yl)-1H-1,3,2-benzodiazaborole試薬HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium触媒HCID 138539Cyclopentyl methyl ether溶媒

反応条件

温度
100 °C

実験手順

The general procedure A was followed using 2-bromothiophene (48.4 uL, 0.5 mmol) and B2pin2 (126.9 mg, 0.5 mmol, 1.0 eq.) as starting material. The resulting mixture was allowed to stir 16 hours at 100 oC. 5t was obtained as orange oil (138.7 mg, 96 %) after purification by silica gel flash chromatography (EtOAc/PE=1:40 v/v);

出典と根拠

ORDレコード
ord-36a20897034c441f9bf4fb79b7aa05c4
出典データセット
Borylation dataset from Roche

反応ノート

読み込み中…