1-(Tert-butoxycarbonyl)indole → tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
反応式
CC(C)(C)OC(=O)n1ccc2ccccc21>C1=CCCC=CCC1.C1=CCCC=CCC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC1CCCC1.C[OH2+].C[OH2+].[Ir].[Ir].c1ccc(N2B(B3Nc4ccccc4N3c3ccccn3)Nc3ccccc32)nc1>CC(C)(C)OC(=O)n1cc(B2OC(C)(C)C(C)(C)O2)c2ccccc21参加物
6
反応物 1
生成物 1
試薬・触媒・溶媒 4
反応条件
- 温度
- 75 °C
実験手順
The general procedure A was followed using tert-butyl 1H-indole-1-carboxylate (108.7 mg, 0.5 mmol.) and B2(pin)2 (101.6 mg, 0.4 mmol, 0.8 eq.) as starting material. The resulting mixture was allowed to stir 16 hours at 75 oC. 5z was obtained as white solid (111.5 mg, 65 %) after purification by silica gel flash chromatography (EtOAc/PE=1:30 v/v). m.p.: 163-165 oC.
出典と根拠
- ORDレコード
- ord-79db2c6eef514d27b2130b1758eb40ff
- 出典データセット
- Borylation dataset from Roche
反応ノート
読み込み中…
