N,N-Dimethyl 2-pyridinecarboxamide → N,N-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)picolinamide

HRID 1490879ノート

反応式

HRID 1490879 の反応式
CN(C)C(=O)c1ccccn1>C1=CCCC=CCC1.C1=CCCC=CCC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.C[OH2+].C[OH2+].Cc1ccc(C)cc1.O=C(Nc1ccccc1-c1ccc(-c2ccccn2)nc1)NC1CCCCC1.[Ir].[Ir]>CN(C)C(=O)c1cc(B2OC(C)(C)C(C)(C)O2)ccn1.CN(C)C(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cn1

参加物

7

反応物 1

HCID 12272694N,N-Dimethyl 2-pyridinecarboxamide

生成物 2

HCID 49760506N,N-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)picolinamide収率 74%HCID 57416491N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxamide収率 12%

試薬・触媒・溶媒 4

HCID 2733548Bis(pinacolato)diborane試薬HCID 91820779HCID 91820779、化合物試薬HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium触媒HCID 7809P-Xylene溶媒

反応条件

温度
25 °C

出典と根拠

ORDレコード
ord-753f2e36bb9640f39382d952bbd9b0c6
出典データセット
Borylation dataset from Roche

反応ノート

読み込み中…