Ethanol → 2-Methylsulphonyl-3-phenylsulphenylbenzoic acid

HRID 1491579ノート

反応式

HRID 1491579 の反応式
[CH3:1][S:2]([C:5]1[C:14]([S:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8])(=[O:4])=[O:3].C(O)C.[OH-].[Na+]>O>[CH3:1][S:2]([C:5]1[C:14]([S:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8])(=[O:4])=[O:3]

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 18953302Methyl 2-methylsulphonyl-3-phenylsulphenylbenzoate

生成物 1

HCID 189533112-Methylsulphonyl-3-phenylsulphenylbenzoic acid収率 99.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of methyl 2 -methylsulphonyl-3-phenylsulphenylbenzoate (8.3 g), ethanol (50 ml) and 2N sodium hydroxide (25 ml) was heated at reflux for one hour and then added to water. The inorganic phase was washed with ethyl acetate, acidified with concentrated hydrochloric acid and extracted with ethyl acetate. This organic phase was dried over sodium sulphate, filtered and evaporated giving 7.9 g of 2-methylsulphonyl-3-phenylsulphenylbenzoic acid as a white solid, m.p. 185.4°-186.0° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for one hour
  3. washThe inorganic phase was washed with ethyl acetate
  4. extractionextracted with ethyl acetate
  5. dry with materialThis organic phase was dried over sodium sulphate
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-2bea5c5b7e5f4d37890d6d902c04f47e
出典データセット
uspto-grants-1994_12
特許番号
US05371064

反応ノート

読み込み中…