Pyrrolidine → HCID 18953550、化合物

HRID 1491639ノート

反応式

HRID 1491639 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>O1CCOCC1>[N:11]1([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])[CH2:15][CH2:14][CH2:13][CH2:12]1

参加物

4

反応物 2

HCID 31268PyrrolidineHCID 27357814-Chloro-3-nitropyridine

生成物 1

HCID 18953550HCID 18953550、化合物収率 95.4%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

4-Chloro-3-nitropyridine (2.02 g, 12.7 mmol) was suspended in 15 ml of 1,4-dioxane. The suspension was cooled a little in an ice bath, and then pyrrolidine (2.1 ml, 25.3 mmol ) was added dropwise thereto. The temperature of the suspension was returned to room temperature, and the suspension was stirred for 30 minutes, followed by removal of the solvent by distillation under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate) to obtain 2.34 g of a yellow solid (yield: 95.4%).

後処理

  1. temperatureThe suspension was cooled a little in an ice bath
  2. customwas returned to room temperature
  3. customfollowed by removal of the solvent by distillation under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (eluent: ethyl acetate)

出典と根拠

ORDレコード
ord-928ee9d366bd43698562826f1125db26
出典データセット
uspto-grants-1994_12
特許番号
US05371086

反応ノート

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