Acetic Anhydride → 6-Acetylaminomethyl-2-pyridinecarbonitrile
反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.Cl.[NH2:9][CH2:10][C:11]1[N:16]=[C:15]([C:17]#[N:18])[CH:14]=[CH:13][CH:12]=1>N1C=CC=CC=1>[C:5]([NH:9][CH2:10][C:11]1[N:16]=[C:15]([C:17]#[N:18])[CH:14]=[CH:13][CH:12]=1)(=[O:7])[CH3:6]参加物
4
実験手順
Acetic anhydride (1.29 ml) was added dropwise to a mixture of 6-aminomethyl-2-pyridinecarbonitrile hydrochloride (2.10 g) in pyridine (21 ml). The solution was stirred for four hours at ambient temperature and evaporated in vacuo. The residue was mixed with aqueous potassium carbonate and extracted with ethyl acetate. The extract was dried over magnesium sulfate and evaporated in vacuo to give 6-(acetylaminomethyl)-2-pyridinecarbonitrile (1.72 g).
後処理
- customevaporated in vacuo
- additionThe residue was mixed with aqueous potassium carbonate
- extractionextracted with ethyl acetate
- dry with materialThe extract was dried over magnesium sulfate
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-39e3b7a8b3d9471bb130a529af6ba0a5
- 出典データセット
- uspto-grants-1994_12
- 特許番号
- US05371097
反応ノート
読み込み中…