6-(Hydroxymethyl)pyridine-2-carboxamide → 6-Formylpicolinamide

HRID 1491821ノート

反応式

HRID 1491821 の反応式
[OH:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1)=[O:1]

参加物

4

反応物 1

HCID 149169816-(Hydroxymethyl)pyridine-2-carboxamide

生成物 1

HCID 189539186-Formylpicolinamide収率 61.3%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

A mixture of 6-hydroxymethyl-2-pyridinecarboxamide (100 g) and manganese dioxide (500 g) in chloroform (2 l) was heated under reflux for 48 hours. Manganese dioxide was removed by filtration and the filtrate was evaporated in vacuo to give 6-formyl-2-pyridinecarboxamide (60.46 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. customManganese dioxide was removed by filtration
  4. customthe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-0d14b8dd3316448dab3144b334b45322
出典データセット
uspto-grants-1994_12
特許番号
US05371097

反応ノート

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