Acetic Anhydride → HCID 10330249、化合物

HRID 1491823ノート

反応式

HRID 1491823 の反応式
[OH:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13].C(OCC)(=O)C.C(=O)([O-])[O-].[K+].[K+]>O1CCCC1.O>[C:12]([O:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1)(=[O:14])[CH3:13]

参加物

7

反応物 4

HCID 7918Acetic AnhydrideHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 149169816-(Hydroxymethyl)pyridine-2-carboxamide

生成物 1

HCID 10330249HCID 10330249、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 6-hydroxymethyl-2-pyridinecarboxamide (80 g) and acetic anhydride (198.8 ml) in tetrahydrofuran (800 ml) was heated under reflux for 24 hours. The reaction mixture was added to a mixture of ethyl acetate and water and the mixture was adjusted to pH 8 with potassium carbonate. The separated organic layer was washed with brine, dried over magnesium sulfate and evaporated to give 6-acetoxymethyl-2-pyridinecarboxamide (93.34 g).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 24 hours
  3. washThe separated organic layer was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-a41b5d5a4df04f98808c4599264e35b0
出典データセット
uspto-grants-1994_12
特許番号
US05371097

反応ノート

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