Acetic Anhydride → 3',5'-Dichloro-4'-hydroxyacetanilide

HRID 1492124

反応式

HRID 1492124 の反応式
Cl.[NH2:2][C:3]1[CH:8]=[C:7]([Cl:9])[C:6]([OH:10])=[C:5]([Cl:11])[CH:4]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>O>[Cl:9][C:7]1[CH:8]=[C:3]([CH:4]=[C:5]([Cl:11])[C:6]=1[OH:10])[NH:2][C:12](=[O:14])[CH3:13]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 162059Phenol, 4-amino-2,6-dichloro-, hydrochloride (1:1)

生成物 1

HCID 100821803',5'-Dichloro-4'-hydroxyacetanilide収率 95%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

Into a 500 ml round bottom flask (fitted with a magnetic stirrer), water (200 ml) was mixed with 4-amino-2,6-dichlorophenol hydrochloride (20 g) until the solid was completely dissolved. The resulting solution was warmed to 70° C., and to it was added acetic anhydride (11 g) and the resulting solution was stirred for 1 hour. Upon cooling, crystals of 3', 5'-dichloro-4'-hydroxyacetanilide formed (19.6 g, 95% yield).

後処理

  1. dissolutionwas completely dissolved
  2. temperatureUpon cooling

出典と根拠

ORDレコード
ord-6ea95674393a4909b3414ba0354333ad
出典データセット
uspto-grants-1994_12
特許番号
US05372931

関連ノート

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