Water → N-(4-hydroxynaphthalen-1-yl)acetamide

HRID 1492127ノート

反応式

HRID 1492127 の反応式
O.[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([OH:13])=[CH:5][CH:4]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15]>C(O)C>[OH:13][C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]([NH:2][C:14](=[O:16])[CH3:15])=[CH:4][CH:5]=1

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 178151-Amino-4-naphthol

生成物 1

HCID 235848N-(4-hydroxynaphthalen-1-yl)acetamide収率 79.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Into a 500 ml round bottom flask (fitted with a magnetic stirrer), a 50:50 mixture of water:ethanol was combined with 4-amino1-naphthol (20 g, 125 mmole) until the solid was completely dissolved. The solution was warmed to boiling, and to it was added acetic anhydride (14 g) and the resulting solution was stirred for 1 hour. Upon cooling, crystals of N-(4-hydroxy-1-naphthyl)acetamide (20 g, 79% yield) formed.

後処理

  1. customInto a 500 ml round bottom flask (fitted with a magnetic stirrer)
  2. dissolutionwas completely dissolved
  3. temperatureThe solution was warmed
  4. temperatureUpon cooling

出典と根拠

ORDレコード
ord-9d36a4eb96e4449bbcd6f139e87e7d73
出典データセット
uspto-grants-1994_12
特許番号
US05372931

反応ノート

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