Sodium Hydroxide → Thieno[3,2-b]pyridine-5-carboxylic acid
反応式
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]=O.[OH-].[Na+].[C:11]([O-:16])(=[O:15])[C:12]([CH3:14])=O.[Na+]>CCO>[S:4]1[C:3]2[C:2](=[N:1][C:12]([C:11]([OH:16])=[O:15])=[CH:14][CH:7]=2)[CH:6]=[CH:5]1参加物
5
反応条件
- 温度
- 60 °C
実験手順
To a solution of 3-amino-2-formylthiophene (10 g, 78 mmol) in EtOH (50 mL) was added a mixture of aqueous NaOH (50 mL, 5%) and sodium pyruvate (17.16 g, 156 mmol). The mixture was heated to 60° C. for 2 hr. The mixture was cooled and washed with Et2O: EtOAc 1:1 and then acidified with 1 N HCl to pH 3 at 0° C. The mixture was filtered and the solid was air dried to give 10 g (71%) of the title compound.
後処理
- temperatureThe mixture was cooled
- washwashed with Et2O: EtOAc 1:1
- customacidified with 1 N HCl to pH 3 at 0° C
- filtrationThe mixture was filtered
- customdried
出典と根拠
- ORDレコード
- ord-f735fc85b2044fddaed3c6a4eaefd8c1
- 出典データセット
- uspto-grants-1994_12
- 特許番号
- US05374635
反応ノート
読み込み中…