P-Cresol → Ethyl (p-tolyloxy)acetate

HRID 1492517

反応式

HRID 1492517 の反応式
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:8][C:3]1[CH:4]=[CH:5][C:6]([O:7][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:1][CH:2]=1

参加物

5

反応物 3

HCID 2879P-CresolHCID 7748Ethyl bromoacetateHCID 11430Potassium Carbonate

生成物 1

HCID 4047281Ethyl (p-tolyloxy)acetate収率 96.6%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

In 70 ml of acetone were suspended 5.00 g of p-cresol, 7.72 g of ethyl bromoacetate and 6.39 g of potassium carbonate, and the resulting mixture was refluxed for 12 hours. After the solvent was distilled off under reduced pressure, water was added to the mixture, followed by extraction with methylene chloride. The organic phase was washed with in aqueous 2N sodium hydroxide solution and then with saturated sodium chloride solution, which was then dried over magnesium sulfate. On evaporation of the solvent under reduced pressure, 8.67 g of ethyl 4-methylphenoxyacetate was produced.

後処理

  1. temperaturethe resulting mixture was refluxed for 12 hours
  2. distillationAfter the solvent was distilled off under reduced pressure, water
  3. additionwas added to the mixture
  4. extractionfollowed by extraction with methylene chloride
  5. washThe organic phase was washed with in aqueous 2N sodium hydroxide solution
  6. dry with materialwith saturated sodium chloride solution, which was then dried over magnesium sulfate
  7. customOn evaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-cdee900a5f4f409ca9c8d2c187058b2f
出典データセット
uspto-grants-1994_12
特許番号
US05374641

関連ノート

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