Water → 1-(Methoxymethoxy)-4-methylbenzene
反応式
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.C(N(C(C)C)CC)(C)C.[CH3:18][O:19][CH2:20]Cl.O>C(Cl)Cl>[CH3:18][O:19][CH2:20][O:7][C:6]1[CH:5]=[CH:4][C:3]([CH3:8])=[CH:2][CH:1]=1参加物
6
実験手順
4-Cresol (59 g) was dissolved in 500 ml of methylene chloride, followed by addition of 238 ml of diisopropylethylamine and 66 g of chloromethyl methyl ether, and stirred at room temperature for two nights. The reaction solution was poured into water, which was then extracted with methylene chloride. After washing in 2N hydrogen chloride and then washing in saturated aqueous sodium chloride, the extract was dried over anhydrous sodium sulfate to yield residue. The residue was subjected to chromatography which was eluted with chloroform, to obtain 4-tolyl methoxymethyl ether.
後処理
- extractionwas then extracted with methylene chloride
- washAfter washing in 2N hydrogen chloride
- washwashing in saturated aqueous sodium chloride
- dry with materialthe extract was dried over anhydrous sodium sulfate
- customto yield residue
- washwas eluted with chloroform
出典と根拠
- ORDレコード
- ord-35b3654269cc4508980188f68ad5e7f7
- 出典データセット
- uspto-grants-1994_12
- 特許番号
- US05374641
反応ノート
読み込み中…