Sodium Hydroxide → HCID 53772361、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH:13]([C:20]2[CH:33]=[CH:32][C:23]([CH:24]=[C:25]([CH3:31])[C:26]([O:28]CC)=[O:27])=[CH:22][CH:21]=2)[C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH:13]([C:20]2[CH:21]=[CH:22][C:23]([CH:24]=[C:25]([CH3:31])[C:26]([OH:28])=[O:27])=[CH:32][CH:33]=2)[C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1参加物
4
実験手順
Ethyl 4-[2-(4-chlorobenzenesulfonamido)-1-(3-pyridyl)ethyl]-α-methylcinnamate (6.8 mg) was dissolved in 1 ml of methanol, followed by addition of 0.2 ml of aqueous 2N sodium hydroxide solution, and refluxed for 18 hours. The solvent was distilled off under reduced pressure. The crystalline deposited through neutralization of the resulting mixture with 2N hydrogen chloride was filtered, to obtain 6.4 mg of 4-[2-(4-chlorobenzenesulfonamido)-1-(3-pyridyl)ethyl]-α-methylcinnamic acid. The spectrometric data thereof supports the structural formula of [49] as follows.