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2-Butyl-5-hydroxymethylimidazole → 2-Butyl-5-formylimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Butyl-5-hydroxymethylimidazole | HCID 2735673 | — |
| 触媒 | HCID 178418406 | HCID 178418406 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-Butyl-5-formylimidazole | HCID 2735671 | 84.8% |
反応手順
To a suspension of 2-butyl-1H-imidazole-5-methanol (2.02 g) in dry dichloromethane (40 ml) and dry dioxan (60 ml) was added manganese dioxide (7.05 g). The reaction mixture was heated at reflux for 3.5 h before being filtered, and the filtrate concentrated in vacuo to give the title compound as a white solid (1.69 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05374646 |
| 出典データセット | uspto-grants-1994_12 |
| ORD ID | ord-6438c970a50e43988334c66cb57dc0f9 |
| 出典メモ | uspto-grants-1994_12 |