Water → p-Octyloxybenzyl alcohol

HRID 1492898

反応式

HRID 1492898 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([O:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[F-].[Na+].O>O1CCCC1>[CH2:7]([O:15][C:16]1[CH:17]=[CH:18][C:19]([CH2:20][OH:21])=[CH:22][CH:23]=1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

参加物

6

反応物 4

HCID 962WaterHCID 5235Sodium FluorideHCID 90358p-(Octyloxy)benzaldehydeHCID 21226445Aluminium lithium hydride

生成物 1

HCID 144261p-Octyloxybenzyl alcohol収率 99.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a suspension of lithium aluminum hydride (4.05 g) in tetrahydrofuran (475 ml) was added dropwise a solution of 4-octyloxybenzaldehyde (25 g) in tetrahydrofuran (25 ml) at 55°~60° C. The reaction mixture was stirred under reflux for 1 hour, and thereto was added sodium fluoride (35.84 g) and water (11.52 ml) under ice-cooling. The mixture was stirred for 30 minutes, and filtrated. The filtrate was evaporated in vacuo to give 4-octyloxybenzyl alcohol (25.1 g) as crystals.

後処理

  1. temperatureunder reflux for 1 hour
  2. temperaturecooling
  3. stirringThe mixture was stirred for 30 minutes
  4. filtrationfiltrated
  5. customThe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-ac6720baaa5b4e6185c20e134142525b
出典データセット
uspto-grants-1994_12
特許番号
US05376634

関連ノート

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