Phthalic Anhydride → HCID 16654924、化合物

HRID 1492922ノート

反応式

HRID 1492922 の反応式
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.Cl.[Cl:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH2:19].C(N(CC)CC)C>C1(C)C=CC=CC=1>[Cl:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]1[C:1](=[O:11])[C:2]2=[CH:10][CH:9]=[CH:8][CH:7]=[C:3]2[C:4]1=[O:6]

参加物

5

反応物 3

HCID 6811Phthalic AnhydrideHCID 8471TriethylamineHCID 189498945-Chloropentan-1-aminato(4-)--hydrogen chlorido(4-) (1/1)

生成物 1

HCID 16654924HCID 16654924、化合物収率 72.5%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 20.6 g (0.139 mole) of phthalic anhydride, 20 g (0.126 mole) of 5-chloropentylamine hydrochloride and 17.6 ml (0.126 mole) of triethylamine in 250 ml of toluene was heated to 130° C. for 4 hours. The obtained mixture was evaporated to dryness. The residue was taken up into 200 ml of water and extracted with ethyl acetate. The phases were separated and the organic phase was dried over sodium sulfate and evaporated to dryness. From the crude product, 23 g of the title product were obtained as an oil having the following characteristics:

後処理

  1. customThe obtained mixture was evaporated to dryness
  2. extractionextracted with ethyl acetate
  3. customThe phases were separated
  4. dry with materialthe organic phase was dried over sodium sulfate
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-8116affbaa734cef96d8a0e07d2b2bf2
出典データセット
uspto-grants-1994_12
特許番号
US05376673

反応ノート

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