N-(oxan-4-ylidene)hydroxylamine → tetrahydropyran-4-one O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-alpha-methylbenzyl}oxime
反応式
[O:1]1[CH2:6][CH2:5][C:4](=[N:7][OH:8])[CH2:3][CH2:2]1.Cl[CH:10]([C:12]1[CH:17]=[CH:16][C:15]([S:18][C:19]2[CH:20]=[C:21]([C:26]3([O:32][CH3:33])[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)[CH:22]=[C:23]([F:25])[CH:24]=2)=[CH:14][CH:13]=1)[CH3:11]>>[F:25][C:23]1[CH:22]=[C:21]([C:26]2([O:32][CH3:33])[CH2:27][CH2:28][O:29][CH2:30][CH2:31]2)[CH:20]=[C:19]([S:18][C:15]2[CH:14]=[CH:13][C:12]([CH:10]([O:8][N:7]=[C:4]3[CH2:5][CH2:6][O:1][CH2:2][CH2:3]3)[CH3:11])=[CH:17][CH:16]=2)[CH:24]=1参加物
3
実験手順
Using an analogous procedure to that described in Example 1, tetrahydropyran-4-one oxime was reacted with 4-{3-[4-(1-chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran to give tetrahydropyran-4-one O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-α-methylbenzyl}oxime as an oil in 74% yield.
出典と根拠
- ORDレコード
- ord-68ce202b88454e78bf074fbdfe5a1f4e