Methyl isothiocyanate → N-Methyl-N'-[2-[[3-(N,N-dimethylaminomethyl)phenyl]methylthio]ethyl]thiourea

HRID 1493184ノート

反応式

HRID 1493184 の反応式
[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([CH2:11][S:12][CH2:13][CH2:14][NH2:15])[CH:8]=[CH:9][CH:10]=1)[CH3:3].[CH3:16][N:17]=[C:18]=[S:19]>C(#N)C>[CH3:16][NH:17][C:18]([NH:15][CH2:14][CH2:13][S:12][CH2:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([CH2:4][N:2]([CH3:1])[CH3:3])[CH:6]=1)=[S:19]

参加物

4

反応物 2

HCID 11167Methyl isothiocyanateHCID 129520192-[[3-(N,N-Dimethylaminomethyl)phenyl]methylthio]ethanamine

生成物 1

HCID 86744815N-Methyl-N'-[2-[[3-(N,N-dimethylaminomethyl)phenyl]methylthio]ethyl]thiourea

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-[[3-(N,N-Dimethylaminomethyl)phenyl]methylthio]ethanamine (5 g) and methyl isothiocyanate (1.62 g) were stirred at room temperature in acetonitrile for 18 hours. The solvent was removed and the residue was column chromatographed on silica using a mixture of ethyl acetate and methanol as eluent to give the title compound as a pale yellow oil. TLC silica; ethyl acetate:isopropanol:water:0.88 ammonia (25:15:8:2) Rf 0.61.

後処理

  1. customThe solvent was removed
  2. customchromatographed on silica using
  3. additiona mixture of ethyl acetate and methanol as eluent

出典と根拠

ORDレコード
ord-04f5ef278ce147c68455c782963f3a1d
出典データセット
uspto-grants-1991_06
特許番号
US05021429

反応ノート

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