1-(4-methoxyphenyl)-4-(6-nitropyridin-3-yl)piperazine → HCID 14986895、化合物

HRID 1493595ノート

反応式

HRID 1493595 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:16]=[CH:17][C:18]([N+:21]([O-])=O)=[N:19][CH:20]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1>C(OCC)(=O)C.[Pt]>[NH2:21][C:18]1[CH:17]=[CH:16][C:15]([N:12]2[CH2:13][CH2:14][N:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[CH2:10][CH2:11]2)=[CH:20][N:19]=1

参加物

4

反応物 1

HCID 48776161-(4-methoxyphenyl)-4-(6-nitropyridin-3-yl)piperazine

生成物 1

HCID 14986895HCID 14986895、化合物

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8857Ethyl Acetate溶媒

実験手順

A suspension of the product of part (i) (0.65 g, 2.0 mmole) in ethyl acetate (30 ml) was hydrogenated over 5% platinum on carbon (25 mg) at 45 p.s.i. (310 kPa) and at 50° for 12 hours, followed by 45 hours at room temperature. The resulting mixture was filtered to remove the catalyst, concentrated under reduced pressure and the residue triturated with ether to yield the desired product, m.p. 182°-188° (0.28 g, 50%), which was used without further purification.

後処理

  1. waitfollowed by 45 hours at room temperature
  2. filtrationThe resulting mixture was filtered
  3. customto remove the catalyst
  4. concentrationconcentrated under reduced pressure
  5. customthe residue triturated with ether

出典と根拠

ORDレコード
ord-4236b47c11214086b5e1a549ff117784
出典データセット
uspto-grants-1991_06
特許番号
US05023258

反応ノート

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