Ethanol → 6-[[2-(2-Ethyl-3,4-dimethoxyphenyl)ethyl]amino]-6-oxohexanoic acid

反応式

[CH2:1]([C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][C:4]=1[CH2:13][CH2:14][NH:15][C:16](=[O:25])[CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23]C)=[O:22])[CH3:2].[OH-].[Na+].C(O)C>O>[CH2:1]([C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][C:4]=1[CH2:13][CH2:14][NH:15][C:16](=[O:25])[CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH3:2]

参加物

実験手順

A mixture of the product from Stage (i) (11 g), 2N sodium hydroxide solution (200 ml) and ethanol (300 ml) was heated under reflux for 1 h. The solution was cooled and poured into water (1000 ml). The mixture was washed with ether, acidified with 2N hydrochloric acid and then extracted with ether. The extracts were washed with water, dried and evaporated to give the title compound (8.4 g) as a white solid, m.p. 92°-94°.