Thionyl Chloride → 2,2-Difluoro-1-methylcyclopropane-1-carbonyl chloride

HRID 1493878

反応式

HRID 1493878 の反応式
[F:1][C:2]1([F:9])[CH2:4][C:3]1([CH3:8])[C:5](O)=[O:6].S(Cl)([Cl:12])=O>>[F:1][C:2]1([F:9])[CH2:4][C:3]1([CH3:8])[C:5]([Cl:12])=[O:6]

参加物

3

反応物 2

HCID 24386Thionyl Chloride2 回HCID 146952292,2-Difluoro-1-methylcyclopropane-1-carboxylic acid

生成物 1

HCID 146952322,2-Difluoro-1-methylcyclopropane-1-carbonyl chloride収率 77%

実験手順

A mixture of 250 g (1.8 mol) of 2,2-difluoro-1-methylcyclopropanecarboxylic acid and 700 ml of thionyl chloride is slowly heated in a distillation apparatus, during which process excess thionyl chloride distills over first and the desired product later. In this manner, 215 g (77% of theory) of 2,2-difluoro-1-methyl-cyclopropanecarbonyl chloride are obtained in form of a liquid of boiling point 121°-122° C. ##STR56##

後処理

  1. distillationdistills over first and the desired product later

出典と根拠

ORDレコード
ord-7b2d3e43e06f4fceb5f1a24097227d99
出典データセット
uspto-grants-1991_06
特許番号
US05025030

関連ノート

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