m-Chloroperbenzoic acid → HCID 10035684、化合物

HRID 1494116ノート

反応式

HRID 1494116 の反応式
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:12]=[CH2:13].ClC1C=CC=C(C(OO)=[O:22])C=1>C(Cl)Cl>[O:22]1[CH:12]([CH2:11][CH2:10][CH2:9][CH2:8][O:7][CH:2]2[CH2:3][CH2:4][CH2:5][CH2:6][O:1]2)[CH2:13]1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 111830362H-Pyran, 2-(5-hexenyloxy)tetrahydro-

生成物 1

HCID 10035684HCID 10035684、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 11.57 g of 6-(2-tetrahydropyranyloxy)-hex-1-ene in 200 mL of methylene chloride is added 10.8 g m-chloroperbenzoic acid and the mixture is stirred at room temperature for 18 hours. The reaction is quenched by the addition of saturated aqueous sodium bicarbonate solution followed by saturated sodium sulfite solution. The organic phase is dried, filtered and evaporated to give a clear oil which is purified by chromatography over silica gel using hexane/ether (4:1) as eluent to obtain 1,2-epoxy-6-(2-tetrahydropyranyloxy)-hexane; IR (CH2CH2): 1450, 1135, 1033 cm-1.

後処理

  1. customThe reaction is quenched by the addition of saturated aqueous sodium bicarbonate solution
  2. customThe organic phase is dried
  3. filtrationfiltered
  4. customevaporated
  5. customto give a clear oil which
  6. customis purified by chromatography over silica gel

出典と根拠

ORDレコード
ord-3de116ba9891495987b88ab44deef977
出典データセット
uspto-grants-1991_06
特許番号
US05025025

反応ノート

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