関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Thiophenol | HCID 7969 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1-Propanone, 2-chloro-2-methyl-1-phenyl- | HCID 81985 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-Propanone, 2-methyl-1-phenyl-2-(phenylthio)- | HCID 12270589 | — |
反応手順
10.88 g of a 50% suspension of sodium hydride in paraffin mineral oil are fed into 100 ml of DMF, followed slowly by 25.11 g of thiophenol. When dissolution is complete (65° C.), the solution is cooled to 2° C. and 36.5 g of 2-chloro-2-methylpropiophenone are fed in over 30 minutes maintaining the temperature below 10° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05026740 |
|---|
| 出典データセット | uspto-grants-1991_06 |
|---|
| ORD ID | ord-5752ad7ba6814d479c4aac8bf2293d7c |
|---|
| 出典メモ | uspto-grants-1991_06 |
|---|
