反应详情

温度

2 °C

10.88 g of a 50% suspension of sodium hydride in paraffin mineral oil are fed into 100 ml of DMF, followed slowly by 25.11 g of thiophenol. When dissolution is complete (65° C.), the solution is cooled to 2° C. and 36.5 g of 2-chloro-2-methylpropiophenone are fed in over 30 minutes maintaining the temperature below 10° C.

1. dissolutionWhen dissolution
2. custom(65° C.)
3. customare fed in over 30 minutes
4. temperaturemaintaining the temperature below 10° C.