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HRID 1494565作成日：2026年10月26日

2-Propoxycarbonylmethyl-4,5-dimethyl-2-oxo-1,3,2-dioxaphospholane → 2,2-Dimethyl-3-(3-propoxy-3-oxo-1-propenyl)-cyclopropane-carboxylic acid

https://huagongshe.com/reaction/1494565

反応式

関与物質

役割名称HCID仕込み量
反応物2-Propoxycarbonylmethyl-4,5-dimethyl-2-oxo-1,3,2-dioxaphospholaneHCID 19828587—
反応物(1R,3S)-3-(Dihydroxymethyl)-2,2-dimethylcyclopropane-1-carboxylic acidHCID 22817332—
生成物2,2-Dimethyl-3-(3-propoxy-3-oxo-1-propenyl)-cyclopropane-carboxylic acidHCID 54570584—

反応手順

Using the procedure of Example 6, 1.26 g of the lactone of (1R,cis) 2,2-dimethyl-3-dihydroxymethyl-cyclopropane-carboxylic acid and 3.13 g of the product of Step A were reacted to obtain after crystallization from hexane 0.89 g of (1R,cis,ΔZ) 2,2-dimethyl-3-[3-oxo-3-propoxy-1-propenyl]-cyclopropane-carboxylic acid melting at 59° C. and having a specific rotation of [α]D20 =+77°±1.5° (c=1% in chloroform).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05026862
出典データセットuspto-grants-1991_06
ORD IDord-9632e8698b904f91b3f051ca77a09363
出典メモuspto-grants-1991_06