Sodium Hydroxide → Ethyl 2,3-dihydro-2-vinyl-1H-indene-2-carboxylate

HRID 1494599

反応式

HRID 1494599 の反応式
[OH-].[Na+].Br[CH2:4][C:5]1[C:6]([CH2:11]Br)=[CH:7][CH:8]=[CH:9][CH:10]=1.[C:13]([O:18][CH2:19][CH3:20])(=[O:17])[CH2:14][CH:15]=[CH2:16]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[CH:15]([C:14]1([C:13]([O:18][CH2:19][CH3:20])=[O:17])[CH2:11][C:6]2[C:5](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:4]1)=[CH2:16]

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 66665o-Bis(bromomethyl)benzeneHCID 74172Ethyl vinylacetate

生成物 1

HCID 19828699Ethyl 2,3-dihydro-2-vinyl-1H-indene-2-carboxylate

試薬・触媒・溶媒 2

HCID 74236Tetrabutylammonium Bromide触媒HCID 1140Toluene溶媒2 回

実験手順

Tetrabutylammonium bromide (0.31 g) and 48% NaOH solution (9 ml) were added to a flask. α,α'-dibromo-o-xylene (5.0 g) in toluene (15 ml) was then added to the flask. The mixture was stirred and ethyl 3-butenoate (2.16 g) in toluene (15 ml) was added dropwise at room temperature. After the addition the temperature was slowly raised to +60° C. The mixture was stirred at this temperature for 3.5 hours and then cooled. The toluene layer was separated, washed with water and evaporated at reduced pressure to give the desired product.

後処理

  1. additionAfter the addition the temperature
  2. temperaturewas slowly raised to +60° C
  3. stirringThe mixture was stirred at this temperature for 3.5 hours
  4. temperaturecooled
  5. customThe toluene layer was separated
  6. washwashed with water
  7. customevaporated at reduced pressure

出典と根拠

ORDレコード
ord-fcd5f311a99c451cb83ce258f6480ff3
出典データセット
uspto-grants-1991_06
特許番号
US05026868

関連ノート

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