Thionyl Chloride → HCID 15087728、化合物

HRID 1494640ノート

反応式

HRID 1494640 の反応式
S(Cl)([Cl:3])=O.[F:5][C:6]1[CH:11]=[CH:10][C:9](/[C:12](/[C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)=[CH:13]\[CH2:14][CH2:15][CH2:16]O)=[CH:8][CH:7]=1>>[Cl:3][CH2:16][CH2:15][CH2:14]/[CH:13]=[C:12](/[C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)\[C:9]1[CH:10]=[CH:11][C:6]([F:5])=[CH:7][CH:8]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 15087804HCID 15087804、化合物

生成物 1

HCID 15087728HCID 15087728、化合物収率 94.4%

実験手順

160 Parts of thionyl chloride were added dropwise to 10 parts of (E)-5-(4-fluorophenyl)-5-(3-pyridinyl)-4-penten-1-ol while stirring (exothermic reaction, the temperature rose to 45° C.). Upon complete addition, stirring was continued for 2 hours at room temperature. The reaction mixture was evaporated. The residue was taken up in methylbenzene and the solvent was evaporated again. The residue was solidified in 2,2'-oxybixpropane. The product was filtered off and dried, yielding 11.5 parts (94.4%) of (E)-3-[5-chloro-1-(4-fluorophenyl)-1-pentenyl]pyridine hdyrochloride (int. 60).

後処理

  1. customexothermic reaction
  2. customrose to 45° C.
  3. additionUpon complete addition
  4. stirringstirring
  5. customThe reaction mixture was evaporated
  6. customthe solvent was evaporated again
  7. filtrationThe product was filtered off
  8. customdried

出典と根拠

ORDレコード
ord-228e13040b974a43ad57c2c02e88fcb8
出典データセット
uspto-grants-1991_06
特許番号
US05026853

反応ノート

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