2-Benzyl-4-nitroisoindoline → Isoindolin-4-amine
反応式
C([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[N+:17]([O-])=O)[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[NH2:17][C:14]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:15]=1[CH2:16][NH:8][CH2:9]2参加物
4
実験手順
11.5 g of 2-benzyl-4-nitroisoindoline was dissolved in 150 ml of methanol and to the solution was added 1.5 g of 10% palladium on carbon. The mixture was stirred under a hydrogen gas stream under atmospheric pressure for one day at room temperature and for another 5 days at 40° C.. The catalyst was removed by filtration and the filtrate was concentrated. The residue was purified by a vacuum distillation (bath temperature: 150°-180° C., pressure: 0.1 mmHg) to obtain 3.74 g of 4-aminoisoindoline.
後処理
- waitfor another 5 days at 40° C.
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated
- distillationThe residue was purified by a vacuum distillation (bath temperature: 150°-180° C., pressure: 0.1 mmHg)
出典と根拠
- ORDレコード
- ord-044d71713e844378a4a53ff6ebfbc9cd
- 出典データセット
- uspto-grants-1991_06
- 特許番号
- US05026856
反応ノート
読み込み中…