Sodium Sulfate → 2-Benzyl-4-hydroxymethylisoindoline

HRID 1494846ノート

反応式

HRID 1494846 の反応式
[CH2:1]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[C:17](OC)=[O:18])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCCC1>[CH2:1]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[CH2:17][OH:18])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 24436Sodium SulfateHCID 19828480Methyl 2-benzylisoindoline-4-carboxylateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 198285052-Benzyl-4-hydroxymethylisoindoline収率 73.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

8.02 g of 2-benzyl-4-methoxycarbonylisoindoline was dissolved in 20 ml of anhydrous tetrahydrofuran and to the solution was added 1.9 g of lithium aluminum hydride. After stirring for 20 hours at room temperature, an aqueous solution of sodium sulfate was added. Insoluble materials were removed by filtration, the filtrate was concentrated, and the residue was recrystallized from ether to give 5.27 g of 2-benzyl-4-hydroxymethylisoindoline.

後処理

  1. customInsoluble materials were removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customthe residue was recrystallized from ether

出典と根拠

ORDレコード
ord-d3612332c92c44609cd395b0ff479db7
出典データセット
uspto-grants-1991_06
特許番号
US05026856

反応ノート

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