Ammonia → 7-Bromoquinolin-5-ol

HRID 1496844ノート

反応式

HRID 1496844 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[C:4]([O:12]C)[CH:3]=1.Br.N>O>[OH:12][C:4]1[CH:3]=[C:2]([Br:1])[CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2

参加物

5

反応物 3

HCID 222AmmoniaHCID 260Hydrogen BromideHCID 712378127-Bromo-5-methoxyquinoline

生成物 1

HCID 1362166197-Bromoquinolin-5-ol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.5 g (0.0064 mol) of 7-bromo-5-methoxy-quinoline were refluxed with 48% HBr (30 ml) for 20h. After cooling to room temperature reaction mixture was poured into 100 ml of water and basified with saturated ammonia solution. Product was filtered off, washed with water and dried at 50° C. in vacuo. Yield of 7-bromo-5-hydroxy-quinoline was 600 mg (41%).

後処理

  1. customreaction mixture
  2. filtrationProduct was filtered off
  3. washwashed with water
  4. customdried at 50° C. in vacuo

出典と根拠

ORDレコード
ord-02bdefb191324228bee808c9a6938667
出典データセット
uspto-grants-2015_12
特許番号
US09199937B2

反応ノート

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