Iodoethane → 2-Ethoxy-4-fluoronitrobenzene

HRID 1496944

反応式

HRID 1496944 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([OH:8])[CH:7]=1.[CH2:12](I)[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([O:8][CH2:12][CH3:13])[CH:7]=1

参加物

5

反応物 3

HCID 6340IodoethaneHCID 99375-Fluoro-2-nitrophenolHCID 11430Potassium Carbonate

生成物 1

HCID 129181532-Ethoxy-4-fluoronitrobenzene

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

5-fluoro-2-nitrophenol (300 mg), ethyliodide (0.50 mL) and potassium carbonate (500 mg) were dissolved in dimethylformamide (DMF, 3 mL), and reacted at 50° C. overnight. The dimethylformamide of the reaction mixture was concentrated under reduced pressure, added with water and the organic layer was extracted with ethyl acetate. The organic layer was washed with brine, and the water was removed with sodium sulfate, and the solvent was removed under reduced pressure. The thus obtained compound was used in the subsequent reaction without further purification.

後処理

  1. customreacted at 50° C. overnight
  2. concentrationThe dimethylformamide of the reaction mixture was concentrated under reduced pressure
  3. additionadded with water
  4. extractionthe organic layer was extracted with ethyl acetate
  5. washThe organic layer was washed with brine
  6. customthe water was removed with sodium sulfate
  7. customthe solvent was removed under reduced pressure
  8. customThe thus obtained compound was used in the subsequent reaction without further purification

出典と根拠

ORDレコード
ord-e9fa60d31de64c67a1bbb8cfa6cdd244
出典データセット
uspto-grants-2015_12
特許番号
US09199944B2

関連ノート

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