Dimethylformamide → 3-Bromo-5-fluorobenzoyl chloride
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:11])[CH:10]=1)[C:5](O)=[O:6].CN(C=O)C.C(Cl)(=O)C([Cl:20])=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:11])[CH:10]=1)[C:5]([Cl:20])=[O:6]参加物
5
実験手順
10 g of 3-bromo-5-fluoro-benzoic acid are suspended in 100 ml of DCM, 0.5 ml DMF and 4.5 ml oxalyl chloride (1.15 Eq) are added and the resulting mixture is stirred for 100 minutes at RT. The solvent is removed by vacuo and the benzoic acid chloride is isolated by distillation.
後処理
- customThe solvent is removed by vacuo
出典と根拠
- ORDレコード
- ord-66fa69f971064cbe863bd8e0e91ff497
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09199947B2
反応ノート
読み込み中…