Hydrochloric Acid → HCID 5312382、化合物

HRID 1497005ノート

反応式

HRID 1497005 の反応式
[C:1]([O:14]CC)(=[O:13])/[CH:2]=[CH:3]/[CH:4]=[CH:5]/[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[OH-].[Na+].Cl>CO>[C:1]([OH:14])(=[O:13])/[CH:2]=[CH:3]/[CH:4]=[CH:5]/[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12387502HCID 12387502、化合物

生成物 1

HCID 5312382HCID 5312382、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

Ethyl (2E,4E)-dodeca-2,4-dienoate (11.84 g) was dissolved in methanol (130 ml) and 2M aqueous sodium hydroxide solution (35 ml) was added. The reaction mixture was heated to 60° C. until full conversion was observed. After cooling down to room temperature the mixture was acidified with diluted aqueous HCl. The reaction mixture was extracted with ethyl acetate and the organic layer was washed with brine, dried over sodium sulfate, and solvents were evaporated. The crude product was used for the next step without further purification.

後処理

  1. temperatureAfter cooling down to room temperature the mixture
  2. extractionThe reaction mixture was extracted with ethyl acetate
  3. washthe organic layer was washed with brine
  4. dry with materialdried over sodium sulfate, and solvents
  5. customwere evaporated
  6. customThe crude product was used for the next step without further purification

出典と根拠

ORDレコード
ord-bf8a9aca678d4fdf98bbda2e9d67e899
出典データセット
uspto-grants-2015_12
特許番号
US09199948B2

反応ノート

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