Benzenamine, 4-chloro-2-(trifluoromethyl)- → 4-Chloro-2-iodo-6-(trifluoromethyl)aniline

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.[I:13]N1C(=O)CCC1=O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([F:10])([F:11])[F:12])[C:5]([NH2:8])=[C:6]([I:13])[CH:7]=1

参加物

反応物 2

HCID 67961Benzenamine, 4-chloro-2-(trifluoromethyl)-

HCID 120273N-Iodosuccinimide

生成物 1

HCID 668656674-Chloro-2-iodo-6-(trifluoromethyl)aniline

実験手順

The title compound was prepared in analogy to example 76 step A from 4-chloro-2-trifluoromethyl-phenylamine (1 g, 5.11 mmol) and N-iodo succinimide (1.73 g, 7.67 mmol). Off white solid. (1.64 g, 88%). GC-MS: 321 (M).

出典と根拠

ORDレコード: ord-46ee168f30784561a5bc042fdbf66e42
出典データセット: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09199938B2

反応ノート

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