Thionyl Chloride → 2-(Chloromethyl)-4-(trifluoromethyl)thiophene
反応式
S(Cl)([Cl:3])=O.[F:5][C:6]([F:15])([F:14])[C:7]1[CH:8]=[C:9]([CH2:12]O)[S:10][CH:11]=1>>[Cl:3][CH2:12][C:9]1[S:10][CH:11]=[C:7]([C:6]([F:15])([F:14])[F:5])[CH:8]=1参加物
3
実験手順
Thionyl chloride (4.89 g) was added to [4-(trifluoromethyl)thiophen-2-yl]methanol (500 mg) at room temperature, and the mixture was stirred for 3 hr. The reaction mixture was concentrated, and the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (275 mg).
後処理
- concentrationThe reaction mixture was concentrated
- customthe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)
出典と根拠
- ORDレコード
- ord-ac6344eb7cb448d9bef47e52838f57dd
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09199963B2
反応ノート
読み込み中…