Hydrogen Bromide → 4-Hydroxy-2-(trifluoromethyl)phenylacetic acid
反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[C:5]([C:13]([F:16])([F:15])[F:14])[CH:4]=1.Br>C(O)(=O)C>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[C:5]([C:13]([F:14])([F:15])[F:16])[CH:4]=1参加物
4
反応条件
- 温度
- 145 °C
実験手順
To a solution of 4-methoxy-2-(trifluoromethyl)phenylacetic acid (500 mg) in acetic acid (5.00 mL) was added a 48% aqueous hydrobromic acid solution (5.00 mL), followed by stirring at 145° C. overnight. The reaction suspension was concentrated under reduced pressure, to the residue was then added water, and the resulting solid was collected by filtration to obtain 4-hydroxy-2-(trifluoromethyl)phenylacetic acid (300 mg).
後処理
- concentrationThe reaction suspension was concentrated under reduced pressure, to the residue
- filtrationadded water, and the resulting solid was collected by filtration
出典と根拠
- ORDレコード
- ord-091c0d1e38d74969933e7ad42515a36f
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09199927B2
反応ノート
読み込み中…