反応式
[C:1]1([C:7]2([C:12]#[N:13])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[C:1]1([C:7]2([CH2:12][NH2:13])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
To a stirred solution of 1-phenyl-cyclopentanecarbonitrile (4 g, 23.5 mmol) in tetrahydrofuran (50 mL) was added lithium aluminium hydride slowly (1M in tetrahydrofuran, 70 ml, 70.6 mmol) and the reaction mixture was stirred at room temperature for 2 h. After completion of the reaction, the reaction mixture was quenched with saturated aqueous Na2SO4 solution slowly at 0° C. It was then filtered and the residue was washed with ethyl acetate. The organic part was concentrated to get C-(1-phenyl-cyclopentyl)-methylamine (8) (2.5 g, crude) as a liquid.
後処理
- customAfter completion of the reaction
- customthe reaction mixture was quenched with saturated aqueous Na2SO4 solution slowly at 0° C
- filtrationIt was then filtered
- washthe residue was washed with ethyl acetate
- concentrationThe organic part was concentrated
出典と根拠
- ORDレコード
- ord-382086c9ccc94cde99b05d0f0dc1da0c
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09199987B2
関連ノート
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