Thionyl Chloride → 3-Chloropyridine-2-carbonyl chloride

HRID 1497693

反応式

HRID 1497693 の反応式
[Cl:1][C:2]1[C:3]([C:8]([OH:10])=O)=[N:4][CH:5]=[CH:6][CH:7]=1.S(Cl)([Cl:13])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:3]([C:8]([Cl:13])=[O:10])=[N:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 8246323-Chloropyridine-2-carboxylic acid

生成物 1

HCID 450814973-Chloropyridine-2-carbonyl chloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
120 °C

実験手順

To a suspension of 3-chloropicolinic acid (1.58 g, 10 mmol) in toluene (6 mL) was added an excess of thionyl chloride (9.52 g, 5.84 mL, 80.0 mmol) at room temperature under a nitrogen atmosphere. The resulting suspension was heated to 120° C. (oil bath temperature) and stirred for 20 h. Then, the solvent and excess of thionyl chloride were removed under vacuum and the residue was dissolved one more time in toluene and the solvent was removed again. The resulting residue was dried under high vacuum and used in the next step.

後処理

  1. customThen, the solvent and excess of thionyl chloride were removed under vacuum
  2. dissolutionthe residue was dissolved one more time in toluene
  3. customthe solvent was removed again
  4. customThe resulting residue was dried under high vacuum

出典と根拠

ORDレコード
ord-0c111a772a66422795d657a647f2ebe2
出典データセット
uspto-grants-2015_12
特許番号
US09199987B2

関連ノート

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