N-bromobutanimide → (2-Amino-5-bromophenyl)(4-chlorophenyl)methanone

HRID 1497712ノート

反応式

HRID 1497712 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)=[O:9].C1C(=O)N([Br:24])C(=O)C1>C(Cl)Cl>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:24])=[CH:4][C:3]=1[C:8]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)=[O:9]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 761662-Amino-4'-chlorobenzophenone

生成物 1

HCID 182477(2-Amino-5-bromophenyl)(4-chlorophenyl)methanone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (2-Amino-phenyl)-(4-chloro-phenyl)-methanone (9.41 g, 0.04 mmol) dissolved in 150 mL DCM was added NBS (7.25 g, 0.04mol) at 0° C. The mixture is stirred at RT for overnight. The mixture is extracted with DCM, washed with NaHCO3, dried over NaSO4 and concentrated. This provides the desired compound. This is used without further purification.

後処理

  1. extractionThe mixture is extracted with DCM
  2. washwashed with NaHCO3
  3. dry with materialdried over NaSO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-7e3a8be07b7c4d17aec8283a2b9f3b27
出典データセット
uspto-grants-2015_12
特許番号
US09199988B2

反応ノート

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