(2-Amino-5-bromophenyl)(4-chlorophenyl)methanone → 2-Methyl-propane-2-sulfinic acid (2-amino-5-bromo-phenyl)-(4-chloro-phenyl)-methyleneamide

HRID 1497713

反応式

HRID 1497713 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)=O.[CH3:18][C:19]([S:22]([NH2:24])=[O:23])([CH3:21])[CH3:20]>C1COCC1>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)=[N:24][S:22]([C:19]([CH3:21])([CH3:20])[CH3:18])=[O:23]

参加物

4

反応物 2

HCID 182477(2-Amino-5-bromophenyl)(4-chlorophenyl)methanoneHCID 3382465Tert-Butanesulfinamide

生成物 1

HCID 1234860542-Methyl-propane-2-sulfinic acid (2-amino-5-bromo-phenyl)-(4-chloro-phenyl)-methyleneamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
80 °C

実験手順

To a solution of (2-Amino-5-bromo-phenyl)-(4-chloro-phenyl)-methanone (13.87 g, 0.05 mol) in THF (200 mL) is added 2-Methyl-propane-2-sulfinic acid amide (6.5 g, 0.05 mol) and Ti(OEt)4 (20.5 g, 0.09 mol).The stirred mixture is refluxed at 80° C. The mixture is quenched with H2O, filtered. THF is removed, extracted with ethyl acetate, dried over NaSO4 and concentrated then purified by silica gel. This produces the desired compound.

後処理

  1. customThe mixture is quenched with H2O
  2. filtrationfiltered
  3. customTHF is removed
  4. extractionextracted with ethyl acetate
  5. dry with materialdried over NaSO4
  6. concentrationconcentrated
  7. customthen purified by silica gel

出典と根拠

ORDレコード
ord-b1e1fe71f526430e872375e4ddd15dbb
出典データセット
uspto-grants-2015_12
特許番号
US09199988B2

関連ノート

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