Hydrochloric Acid → 5-(2-Methoxyphenyl)-2-methylfuran-3-carboxylic acid

反応式

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:13][C:12]([CH3:14])=[C:11]([C:15]([O:17]CC)=[O:16])[CH:10]=1.[OH-].[Na+].Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:13][C:12]([CH3:14])=[C:11]([C:15]([OH:17])=[O:16])[CH:10]=1

参加物

実験手順

Ethyl 5-(2-methoxyphenyl)-2-methylfuran-3-carboxylate (1.00 g, 3.84 mmol) prepared in the Step 20-1-2 was dissolved in ethanol (8 ml), and a 1 mol/ml sodium hydroxide aqueous solution (8 ml) was added thereto. The mixture was heated under reflux for about 40 minutes. After being allowed to cool, the mixture was adjusted to weak acidity with 2 mol/ml hydrochloric acid, and the precipitate was filtered. The residue was washed with water and dried to give the title compound (0.95 g, quantitative) as a white powder.