Hydrazine hydrate (1:1) → {1-[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]ethylidene}-hydrazine
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:14](=O)[CH3:15])=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1.O.[NH2:18][NH2:19]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:14](=[N:18][NH2:19])[CH3:15])=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1参加物
4
実験手順
In ethanol (10 ml), 1-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]-ethanone (205 mg) prepared in the Step 30-1-1 was dissolved, and hydrazine monohydrate (1.2 g) was added thereto. The mixture was heated under reflux for 21 hours. The mixture was concentrated under a reduced pressure, and then water was added thereto. The precipitated crystal was separated by filtration, washed with water, and dried to give the title compound (196 mg, 91%).
後処理
- dissolutionwas dissolved
- temperatureThe mixture was heated
- temperatureunder reflux for 21 hours
- concentrationThe mixture was concentrated under a reduced pressure
- additionwater was added
- customThe precipitated crystal was separated by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-0cbd339fc16e485bb5eacdca582ab373
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09200008B2
反応ノート
読み込み中…