2-(4-Chlorophenyl)-4-methyl-1,3-thiazole-5-carbohydrazide → HCID 68642106、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:14]([NH:16][NH2:17])=[O:15])=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1.[OH:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])[C:22](Cl)=[O:23]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:14]([NH:16][NH:17][C:22](=[O:23])[C:21]3[CH:25]=[CH:26][C:27]([O:28][CH3:29])=[C:19]([OH:18])[CH:20]=3)=[O:15])=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1参加物
4
実験手順
In pyridine (4 ml), 2-(4-chloro-phenyl)-4-methyl-thiazole-5-carboxylic acid hydrazide (120 mg) and 3-hydroxy-4-methoxy-benzoyl chloride (84 mg) were stirred for 24 hours at a room temperature. The mixture was concentrated under a reduced pressure, and then diluted hydrochloric acid was added thereto. The precipitated crystal was separated by filtration and dried, and the resulting crystal was recrystallized from ethanol to give the title compound (46 mg, 24%).