Ethyl trifluoroacetate → 2,2,2-Trifluoro-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethan-1-one

HRID 1499390ノート

反応式

HRID 1499390 の反応式
[NH:1]1[CH2:7][CH2:6][CH2:5][C@H:2]1[CH2:3][OH:4].[F:8][C:9]([F:16])([F:15])[C:10](OCC)=[O:11]>C1COCC1>[F:8][C:9]([F:16])([F:15])[C:10]([N:1]1[CH2:7][CH2:6][CH2:5][C@H:2]1[CH2:3][OH:4])=[O:11]

参加物

4

反応物 2

HCID 9794Ethyl trifluoroacetateHCID 640091L-Prolinol2 回

生成物 1

HCID 186601442,2,2-Trifluoro-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethan-1-one収率 97%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒4 回

実験手順

L-prolinol (2.0 g, 20 mmol) was dissolved in 20 ml of THF. On the other hand, ethyl trifluoroacetate (3.0 g, 21 mmol) was dissolved in 20 ml of THF. Then, the latter THF solution was instilled in the former THF solution containing the L-prolinol, and this was stirred for 12 hours. This reaction solution was vacuum concentrated. Thus, Compound 1 was obtained (3.7 g, yield: 97%). The result of NMR analysis with respect to this compound is shown below.

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-0a59108308d945248d981e0bbc23ca2e
出典データセット
uspto-grants-2015_12
特許番号
US09200278B2

反応ノート

読み込み中…